Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism
Identifieur interne : 004243 ( Main/Exploration ); précédent : 004242; suivant : 004244Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism
Auteurs : F. J. G. Vingerhoets [Canada] ; F. J. G. Snow [Canada] ; C. S. Lee [Canada] ; M. Schulzer [Canada] ; E. Mak [Canada] ; D. B. Calne [Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 1994-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Dihydroxyphenylalanine (analogs & derivatives), Disease Progression, Emission tomography, Evolution, Exploration, Female, Human, Humans, Male, Middle Aged, Parkinson Disease (diagnostic imaging), Parkinson disease, Positron, Substantia Nigra (diagnostic imaging), Tomography, Emission-Computed (methods).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- diagnostic imaging : Parkinson Disease, Substantia Nigra.
- methods : Tomography, Emission-Computed.
- Adult, Aged, Disease Progression, Female, Humans, Male, Middle Aged.
Abstract
Previous estimates of the rate of progression of the nigral pathology underlying idiopathic parkinsonism (IP) have been derived mainly from pathological studies that have an inherent selection bias. Fluorodopa positron emission tomography (PET) is a reliable tool for assessing nigrostriatal dopaminergic function in vivo. We performed fluorodopa PET on two occasions, 7 years apart, on 16 patients with IP (age at the time of the first scan, 51 ± 14 yr [mean ± SD]) and 10 normal controls (age, 54 ± 16 yr). For the patients with IP, the average duration of symptoms from the time of diagnosis to the first scan was 4.5 years (range, 1–12 yr); their PET index (striatal – occipital)/occipital ratio, dropped by 1.7% per year, from 0.49 ± 0.08 to 0.43 ± 0.08 (p < 0.001). The normals' ratio decreased by 0.3% per year from 0.77 ± 0.05 to 0.75 ± 0.10 (p = 0.33). The ratios in the IP group progressed significantly faster than the controls (p = 0.036). The rate of decline in IP represents 7.8% per decade, expressed as a fraction of the normals' initial mean value at 54 years of age. These results also permit power analysis for the design of future studies assessing the effect of treatment on the underlying pathology in IP.
Url:
DOI: 10.1002/ana.410360512
Affiliations:
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Le document en format XML
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Calne</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre, University Hospital, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994-11">1994-11</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="759">759</biblScope><biblScope unit="page" to="764">764</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">548AB9485B4F72079E74954D09818F59057F90E9</idno><idno type="DOI">10.1002/ana.410360512</idno><idno type="ArticleID">ANA410360512</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Disease Progression</term><term>Emission tomography</term><term>Evolution</term><term>Exploration</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson disease</term><term>Positron</term><term>Substantia Nigra (diagnostic imaging)</term><term>Tomography, Emission-Computed (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Evolution</term><term>Exploration</term><term>Fluorodopa</term><term>Homme</term><term>Parkinson maladie</term><term>Positon</term><term>Tomoscintigraphie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous estimates of the rate of progression of the nigral pathology underlying idiopathic parkinsonism (IP) have been derived mainly from pathological studies that have an inherent selection bias. Fluorodopa positron emission tomography (PET) is a reliable tool for assessing nigrostriatal dopaminergic function in vivo. We performed fluorodopa PET on two occasions, 7 years apart, on 16 patients with IP (age at the time of the first scan, 51 ± 14 yr [mean ± SD]) and 10 normal controls (age, 54 ± 16 yr). For the patients with IP, the average duration of symptoms from the time of diagnosis to the first scan was 4.5 years (range, 1–12 yr); their PET index (striatal – occipital)/occipital ratio, dropped by 1.7% per year, from 0.49 ± 0.08 to 0.43 ± 0.08 (p < 0.001). The normals' ratio decreased by 0.3% per year from 0.77 ± 0.05 to 0.75 ± 0.10 (p = 0.33). The ratios in the IP group progressed significantly faster than the controls (p = 0.036). The rate of decline in IP represents 7.8% per decade, expressed as a fraction of the normals' initial mean value at 54 years of age. These results also permit power analysis for the design of future studies assessing the effect of treatment on the underlying pathology in IP.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Vingerhoets, F J G" sort="Vingerhoets, F J G" uniqKey="Vingerhoets F" first="F. J. G." last="Vingerhoets">F. J. G. Vingerhoets</name></noRegion><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C. S." last="Lee">C. S. Lee</name><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name><name sortKey="Snow, F J G" sort="Snow, F J G" uniqKey="Snow F" first="F. J. G." last="Snow">F. J. G. Snow</name><name sortKey="Snow, F J G" sort="Snow, F J G" uniqKey="Snow F" first="F. J. G." last="Snow">F. J. G. Snow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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